In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Danazol treatment may interfere with laboratory determinations of testosterone, androstenedione and dehydroepiandrosterone. Other metabolic events include a reduction in thyroid binding globulin and T4 with increased uptake of T3, but without disturbance of thyroid stimulating hormone or of free thyroxin index. Your pharmacist can provide more information about sirolimus. Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.
Rabinowe SN, Miller KB "Danazol-induced thrombocytopenia. What is the most important information I should know about danazol Danocrine? RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions.
Stir the mixture and drink all of it right away. Danazol is a man-made form of a steroid. Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant. Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. If you experience bloating or swelling of the ankles, fainting or dizziness, headache, weakness, fatigue, irregular heartbeat, difficulty speaking, double vision, stomach pain, changes in the frequency of bowel movements, persistent sore throat or fever, joint pain or leg cramps, fever, yellowing of the skin, or dark urine, contact your doctor. It may be necessary to monitor your blood levels of carbamazepine. Your doctor may want to adjust the dose of your medicine.
An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking danazol? In female patients, the use of danazol the active ingredient contained in Danocrine may result in virilization including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization. Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported.
Before initiating therapy of fibrocystic breast disease with Danazol, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out. Martino S "Danazol induced hypercalcemia in breast cancer. MACE in association with use of testosterone replacement therapy in men. If this occurs, the drug should be discontinued. The oral liquid solution comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol Capsules USP are usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy. If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine. Williams G "Metabolic effects of danazol.
Breastfeeding. 5. Porphyria - Danazol can induce ALA synthetase activity and hence porphyrin metabolism. 6. Androgen-dependent tumor. 7. Active thrombosis or thromboembolic disease and history of such events. 8. Hypersensitivity to Danazol. There are no data on the excretion of danazol into human milk. Breast-feeding is considered to be contraindicated by the manufacturer. What other drugs will affect sirolimus Rapamune? Overdose symptoms may include some of the serious side effects listed in this medication guide. Using this medicine may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking this medicine, check with your doctor right away. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. What should I avoid while taking sirolimus Rapamune? In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended. Therapy with Danazol may cause an increase in carbamazepine levels in patients taking both drugs. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. The following reactions have been reported, a causal relationship to the administration of Danazol has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis and splenic peliosis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. Further, food also delayed mean time to peak concentration of Danocrine by about 30 minutes.
Oncologic side effects have included rare cases of hepatic neoplasms following prolonged use. Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Our Danocrine danazol Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. Barbieri RL "Danazol and thyroid function. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Yaginuma T, Okamura T, Takeuchi T, Nishii O, Fujimori R "Preventive effect of traditional herbal medicine, shosaiko-to, on danazol-induced hepatic damage. In moderate to severe disease, or in patients due to endometriosis, a starting dose of 800 mg Danocrine given in two divided doses is recommended. The total daily dosage of Danocrine for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. It should not be given intravenously. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Do NOT take more medicine than prescribed unless advised to do so by your doctor. Your medication needs may change if you become ill, have a fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you. Do not change your medication dose or schedule without your doctor's advice. It is very important that your doctor check your progress at regular visits to make sure that this medicine does not cause unwanted effects. Blood tests may be needed to check for unwanted effects.
Use a barrier form of birth control such as a condom or diaphragm with spermicide. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective enough to prevent pregnancy during your treatment with danazol. Nakajima T, Mizushima N, Matsuda H, Matsumoto M, Tamakoshi K, Ishii H, Morioka S, Ikeda Y, Terao T, Kanai K "Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Case report. The physician therefore should be alert to this possibility. Product Information. Danocrine danazol. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Danazol is lipophilic and can partition into cell membranes, indicating the likelihood of distribution into deep tissue compartments. Makdisi WJ, Cherian R, Vanveldhuizen PJ, Talley RL, Stark SP, Dixon AY "Fatal peliosis of the liver and spleen in a patient with agnogenic myeloid metaplasia treated with danazol. In the treatment of fibrocystic breast disease, Danazol usually produces partial to complete disappearance of nodularity and complete relief of pain and tenderness. Changes in the menstrual pattern may occur. Moderate. These medicines may cause some risk when taken together.
Miller EJ, Coleman FH "Pseudohypertestosteronemia during danazol therapy. A case report. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Danocrine can induce ALA synthetase activity and hence porphyrin metabolism. What are the possible side effects of sirolimus Rapamune? Do not use danazol if you are pregnant. It may cause serious harm to a fetus. It is recommended that a pregnancy test be performed before starting danazol. Effective, nonhormonal birth control measures, such as diaphragms and condoms, should be used while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If you become pregnant while taking danazol, stop use and contact your doctor right away. What happens if I miss a dose Danocrine? Reversible oligospermia may occur in adult males after prolonged administration or excessive dosage. If this effect occurs, danazol can be discontinued and if restarted, a lower dosage should be utilized. Preliminary epidemiological evidence suggests that the use of danazol might increase the baseline risk of ovarian cancer in patients being treated for endometriosis.
An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking Danocrine danazol? What should I discuss with my doctor before taking sirolimus Rapamune? Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Ronnberg L, Jarvinen PA "Pregnancy rates following various therapy modes for endometriosis in infertile patients. Experience with long-term therapy with danazol is limited. Store at room temperature away from moisture and heat. What happens if I miss a dose? If therapy is not initiated during menstruation, a sensitive pregnancy test that detects early pregnancy should be done to determine that the patient is not pregnant. A non-hormonal contraceptive method should be used during danazol therapy. If pregnancy occurs during therapy, danazol should be discontinued. Patients should be advised of the possible risks to the fetus. In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Your doctor may occasionally change your dose to make sure you get the best results. Because Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Serious and sometimes fatal blood clots eg, stroke increased pressure in the head, and liver problems have been reported with the use of danazol. Notify your doctor immediately if you develop any of the following: calf or leg pain, redness, tenderness, or swelling; chest pain; fainting; headache; nausea or vomiting; shortness of breath; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; vision changes.
Danocrine in the early 90's to treat endometriosis. I was supposed to take it for about 9 months to "simulate pregnancy" by stopping my menstrual cycle long enough to "heal". I could only do it for 3 months, because the side effects were awful. Hayden M, Buchanan N. Danazol-carbamazepine interaction. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Baker HW, Snedecor PA "Clinical trial of danazol for benign breast disease. If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation. How should I take danazol? Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Gray RG "Bilateral carpal tunnel syndrome and arthritis associated with Danazol administration. LLC Bridgewater, New Jersey 08807. Revised December 2011. Danocrine suppresses the pituitary-ovarian axis. This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danocrine depresses the output of both follicle-stimulating hormone FSH and luteinizing hormone LH. Andriole GL, Brickman C, Lack EE, Sesterhenn IA, Javadpour N, Linehan WM, Frank MM "Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare.
The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Side Effects List Danocrine Capsule side effects by likelihood and severity. What should I avoid while taking danazol Danocrine? Hematologic side effects have included thromboembolic and thrombophlebotic events including sagittal sinus thrombosis some resulting in fatal strokes, and increased red cell production. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting. Hepatic side effects have included life-threatening peliosis hepatitis and benign hepatic adenoma following prolonged danazol the active ingredient contained in Danocrine administration. Rare cases of hepatic neoplasms following prolonged use have been reported. Danazol can exacerbate acute intermittent porphyria. Serum transaminase levels may be increased. Danazol Capsules USP are indicated for the treatment of endometriosis amenable to hormonal management. Lipitor, Caduet fluvastatin Lescol lovastatin Mevacor, Altoprev, Advicor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Vytorin, Juvisync. Danazol Capsules USP are indicated for the prevention of attacks of angioedema of all types cutaneous, abdominal, laryngeal in males and females. Because Danocrine may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus.
Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. Use of Danazol in pregnancy is contraindicated. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. Danocrine danazol is a used to treat and fibrocystic breast disease. Danocrine is also used to prevent attacks of in people with an inherited form of this disorder. The brand name Danocrine is discontinued, but versions may be available. Danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Danazol should not be administered to patients with: 1. Undiagnosed abnormal genital bleeding. 2. Markedly impaired hepatic, renal, or cardiac function. 3. Pregnancy. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients with these symptoms should be screened for papilledema and, if present, the patients should be advised to discontinue danazol immediately and be referred to a neurologist for further diagnosis and care. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder hereditary angioedema. You may need to have a negative pregnancy test before starting this treatment. Wardle PG, Whitehead MI, Mills RP "Non-reversible and wide ranging voice changes after treatment with danazol. Absorption: After oral administration of a 400 mg dose to healthy male volunteers, peak plasma concentrations of Danazol are reached between 2 and 8 hours, with a median T max value of 4 hours. Steady state conditions are observed following 6 days of twice daily dosing of Danazol. Danazol suppresses the pituitary-ovarian axis. This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of Danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danazol depresses the output of both follicle-stimulating hormone FSH and luteinizing hormone LH. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules see and . It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted. Store sirolimus oral liquid in the refrigerator. Do not freeze. You may notice a slight haze to the liquid after it has been refrigerated. This haze will not affect the medication, and should disappear when the medicine reaches room temperature.
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Danazol has rarely caused very serious possibly fatal blood clots such as stroke liver disease, and increased pressure on the brain benign intracranial hypertension. Store danazol at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep danazol out of the reach of children and away from pets. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. If any of these effects persist or worsen, tell your doctor or promptly.
Endometriosis patients - You must take danazol consistently for 3 to 6 months. It may be necessary to take danazol for 9 months. Avoid getting sirolimus liquid on your skin or around your nose. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water. All medicines may cause side effects, but many people have no, or minor, side effects.
Follow your doctor's instructions about any restrictions on food, beverages, or activity. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment.
Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danocrine on the pituitary-ovarian axis. Markedly impaired hepatic, renal, or cardiac function. Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. What should I discuss with my healthcare provider before taking danazol?